产品货号：
GS4687
中文名称：
重组小鼠IL-36α(153a.a.)
英文名称：
Recombinant Murine Interleukin-36 alpha, 153a.a.
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 17.1kDa,a single non-glycosylated polypeptide chain containing 153 amino acids.
储存条件：冷冻（-20℃）
概述
Interleukin-36(IL-36)is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36α,IL-36β,and IL-36γ(formerly IL-1F6,IL-1F8,and IL-1F9)are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2(IL-1RL2)and IL-1RAcP.IL-36α is mainly found in skin and lymphoid tissues,but also in fetal brain,trachea,stomach and intestine.It is expressed by monocytes,B and T cells.Notably,IL-36 alpha is the only novel IL-1 family member expressed on T-cells.Recombinant murine interleukin-36 alpha contains 153 amino acids residues which is a single non-glycosylated polypeptide.Specifically,mouse IL-36α shares 83%a.a.sequence identity with rat IL-36α,54 – 60%with human,rabbit,equine and bovine IL-36α.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组小鼠IL-36α(153a.a.)，IL-36α, 153a.a., Murine，Recombinant Murine Interleukin-36 alpha, 153a.a.
储存条件：冷冻（-20℃）
概述
Interleukin-36(IL-36)is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36α,IL-36β,and IL-36γ(formerly IL-1F6,IL-1F8,and IL-1F9)are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2(IL-1RL2)and IL-1RAcP.IL-36α is mainly found in skin and lymphoid tissues,but also in fetal brain,trachea,stomach and intestine.It is expressed by monocytes,B and T cells.Notably,IL-36 alpha is the only novel IL-1 family member expressed on T-cells.Recombinant murine interleukin-36 alpha contains 153 amino acids residues which is a single non-glycosylated polypeptide.Specifically,mouse IL-36α shares 83%a.a.sequence identity with rat IL-36α,54 – 60%with human,rabbit,equine and bovine IL-36α.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by inducing IL-6 secretion in murine NIH/3T3 cells is less than 25ng/ml,corresponding to a specific activity of>4.0×104 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,1mMDTT,3%trehalose. |
| 内毒素 | Less than 1 EU/μg of rMuIL-36α,153a.a.as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/ml.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | RAASPSLRHV QDLSSRVWIL QNNILTAVPR KEQTVPVTIT LLPCQYLDTL ETNRGDPTYM GVQRPMSCLF CTKDGEQPVL QLGEGNIMEM YNKKEPVKAS LFYHKKSGTT STFESAAFPG WFIAVCSKGS CPLILTQELG EIFITDFEMI VVH |
相关搜索：重组小鼠IL-36α(153a.a.)，IL-36α, 153a.a., Murine，Recombinant Murine Interleukin-36 alpha, 153a.a.